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Curr Urol Rep. This is an excellent summary of the current literature on the treatment and diagnosis of neurogenic refractory overactive bladder. A systematic review and meta-analysis of randomized controlled trials with antimuscarinic drugs for overactive bladder. Eur Urol. Long-term adherence to antimuscarinic therapy in everyday practice: a systematic review.
Overactive bladder medication adherence when medication is free to patients. Mechanisms of action of botulinum neurotoxins, beta3-adrenergic receptor agonists, and PDE5 inhibitors in modulating detrusor function in overactive bladders: ICI-RS Excellent description and illustration of the mechanisms of B3-agonists and botox on the lower urinary tract. Comparative efficacy and safety of medical treatments for the management of overactive bladder: a systematic literature review and mixed treatment comparison. This meta-analysis of several randomized control trials found that B3-agonist had no difference in efficacy with fewer side effects than antimuscarinics.
Int Urol Nephrol.
Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study symphony. The first phase 2 trial supporting the use of combination therapy, B3-agonists and antimuscarinics, is safe and possibly more efficacious. Urol Pract. The authors recommend a treatment algorithm for refractory overactive bladder based on the current and relevant literature.
Balchandra P, Rogerson L. Int Urogynecol J.
Excellent prospective study into factors that influence treatment decisions for refractory overactive bladder. Phase 3 efficacy and tolerability study of onabotulinumtoxinA for urinary incontinence from neurogenic detrusor overactivity. A randomized, multicenter, placebo controlled study that reported on the safety and efficacy of vs units botox for neurogenic bladder.
Significant improvements were found in overactive bladder symptoms and quality of life. OnabotulinumtoxinA for the treatment of patients with overactive bladder and urinary incontinence: results of a phase 3, randomized, placebo controlled trial. An excellent phase 3 trial that lead to FDA approval, which reported on the safety and efficacy of botox for refractory idiopathic overactive bladder.
Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial. Another of the randomized, multicenter, placebo controlled study that reported on the safety and efficacy of vs units botox for neurogenic bladder.
Potential risk factors and outcomes of artificial urinary sphincter placement after radical cystectomy and orthotopic neobladder urinary diversion. Long-term outcome of the use of intravesical botulinum toxin for the treatment of overactive bladder OAB. BJU Int. Repeated botulinum toxin type A injections for refractory overactive bladder: medium-term outcomes, safety profile, and discontinuation rates.
Types of Urinary Incontinence
Short-term efficacy of botulinum toxin a for refractory overactive bladder in the elderly population. Increased risk of large post-void residual urine and decreased long-term success rate after intravesical onabotulinumtoxinA injection for refractory idiopathic detrusor overactivity. How sacral nerve stimulation neuromodulation works.
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- Overactive Bladder (OAB) Guideline - American Urological Association.
- Overactive bladder: evaluation and management in primary care..
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Urol Clin N Am. Sacral neuromodulation for neurogenic lower urinary tract dysfunction: systematic review and meta-analysis. This is a meta-analysis of sacral neuromodulation for neurogenic overactive bladder. Sacral neuromodulation and refractory overactive bladder: an emerging tool for an old problem. Ther Adv Urol. Results of sacral neuromodulation therapy for urinary voiding dysfunction: outcomes of a prospective, worldwide clinical study.
Results of a prospective, randomized, multicenter study evaluating sacral neuromodulation with InterStim therapy compared to standard medical therapy at 6-months in subjects with mild symptoms of overactive bladder. This study showed the benefit sacral neuromodulation over medications for overactive bladder. Does sacral nerve stimulation improve global pelvic function in women?
Randomized trial of percutaneous tibial nerve stimulation versus Sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT trial. Excellent percutaneous tibial nerve stimulation vs validated sham demonstrating improved overactive bladder outcomes and quality of life. This pivotal study lead to FDA approval of percutaneous tibial nerve stimulation. Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial.
Maintenance percutaneous posterior nerve stimulation for refractory lower urinary tract symptoms in patients with multiple sclerosis: an open label, multicenter, prospective study. This causes a person to feel a sudden and sometimes overwhelming urge to urinate even when the bladder is not full. They were evaluated with questionnaires.
Overactive Bladder - Assessment Tool - Urology Care Foundation
Behavioral therapy was recommended to In the first visit, Side-effects occurred in These include dry mouth, dry skin, and blurred vision. However, few patients 1. This study had a very short follow-up period of 4 months.
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- Overactive bladder: evaluation and management in primary care. - Abstract - Europe PMC.
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Also, many patients did not return to follow-up visits. This might have changed the results. The real-life management of overactive bladder: Turkish Continence Society multicenter prospective cohort study with short-term outcome. To receive all the cutting-edge updates personally relevant to you.